RBFE network

Selected edges are shown below with both ligands drawn side by side. The warm highlight is the soft-core region that changes during the transformation; the cool highlight is the common core that stays fixed.

16
Ligands
45
Edges
17
Repaired
0
Rejected
redundant-mst
Planner

Diagnostics

Network-level metrics. Machine time is estimated from published per-edge measurements and is a report only -- it played no part in choosing these edges.

MetricValue
Total cost54.370 scorer units
Estimated machine time178.7 GPU-hours (about $71.46)
Mean cost per edge1.208
Degreemin 3 · mean 5.62 · max 11
Isolated ligandsnone
Diameter4
Short cycles188 of length ≤ 4
Robustness100% of 100 trials stay connected at 5% edge failure; 16.0 ligands retained on average

45 edges over 16 ligands meets the n*ln(n) precision floor of 45.

Network

ejm31 - ejm42: cost 0.347ejm31 - ejm43: cost 1.301ejm31 - ejm44: cost 1.300ejm31 - ejm46: cost 1.964ejm31 - ejm50: cost 0.431ejm31 - ejm54: cost 0.945ejm31 - ejm55: cost 0.447ejm42 - ejm43: cost 0.588ejm42 - ejm46: cost 1.885ejm42 - ejm50: cost 0.674ejm42 - ejm55: cost 1.544ejm43 - ejm44: cost 0.917ejm43 - ejm46: cost 1.990ejm43 - ejm50: cost 1.654ejm43 - ejm54: cost 1.777ejm44 - ejm50: cost 1.762ejm44 - ejm54: cost 1.886ejm45 - ejm46: cost 1.191ejm45 - ejm47: cost 1.346ejm45 - ejm48: cost 1.660ejm45 - jmc27: cost 1.173ejm45 - jmc28: cost 1.185ejm46 - ejm47: cost 1.759ejm46 - ejm49: cost 1.904ejm46 - ejm54: cost 1.926ejm46 - jmc23: cost 0.273ejm46 - jmc27: cost 0.387ejm46 - jmc28: cost 0.322ejm46 - jmc30: cost 0.620ejm47 - ejm48: cost 1.983ejm47 - jmc23: cost 1.785ejm47 - jmc27: cost 1.790ejm47 - jmc28: cost 1.762ejm48 - ejm49: cost 1.938ejm49 - jmc27: cost 1.892ejm49 - jmc28: cost 1.897ejm50 - ejm54: cost 1.267ejm50 - ejm55: cost 0.935ejm54 - ejm55: cost 1.488jmc23 - jmc27: cost 0.328jmc23 - jmc28: cost 0.276jmc23 - jmc30: cost 0.558jmc27 - jmc28: cost 0.294jmc27 - jmc30: cost 0.474jmc28 - jmc30: cost 0.545ejm31 (degree 7)ejm31ejm31ejm42 (degree 5)ejm42ejm42ejm43 (degree 6)ejm43ejm43ejm44 (degree 4)ejm44ejm44ejm45 (degree 5)ejm45ejm45ejm46 (degree 11)ejm46ejm46ejm47 (degree 6)ejm47ejm47ejm48 (degree 3)ejm48ejm48ejm49 (degree 4)ejm49ejm49ejm50 (degree 6)ejm50ejm50ejm54 (degree 6)ejm54ejm54ejm55 (degree 4)ejm55ejm55jmc23 (degree 5)jmc23jmc23jmc27 (degree 7)jmc27jmc27jmc28 (degree 7)jmc28jmc28jmc30 (degree 4)jmc30jmc30

Thicker edges are cheaper. Hollow red nodes are unconnected. Click a network edge or the index below to jump to its transformation card.

Selected edges

soft-core (transformed)common core (held fixed)
ejm46~jmc23cost 0.273 · soft-core 1/1 · common core 35jmc23~jmc28cost 0.276 · soft-core 1/4 · common core 35jmc27~jmc28cost 0.294 · soft-core 1/4 · common core 35ejm46~jmc28cost 0.322 · soft-core 1/4 · common core 35jmc23~jmc27cost 0.328 · soft-core 1/1 · common core 35ejm31~ejm42cost 0.347 · soft-core 1/4 · common core 31ejm46~jmc27cost 0.387 · soft-core 1/1 · common core 35ejm31~ejm50cost 0.431 · soft-core 1/2 · common core 31ejm31~ejm55cost 0.447 · soft-core 4/5 · common core 28jmc27~jmc30cost 0.474 · soft-core 1/2 · common core 35jmc30~jmc28cost 0.545 · soft-core 2/4 · common core 35jmc23~jmc30cost 0.558 · soft-core 1/2 · common core 35ejm42~ejm43cost 0.588 · soft-core 1/4 · common core 34ejm46~jmc30cost 0.620 · soft-core 1/2 · common core 35ejm50~ejm42cost 0.674 · soft-core 2/4 · common core 31ejm43~ejm44cost 0.917 · soft-core 1/4 · common core 37ejm50~ejm55cost 0.935 · soft-core 5/5 · common core 28ejm31~ejm54cost 0.945 · soft-core 4/9 · common core 28jmc27~ejm45cost 1.173 · soft-core 8/11 · common core 28ejm45~jmc28cost 1.185 · soft-core 11/11 · common core 28ejm46~ejm45cost 1.191 · soft-core 8/11 · common core 28ejm50~ejm54cost 1.267 · soft-core 5/9 · common core 28ejm31~ejm44cost 1.300 · soft-core 4/13 · common core 28ejm31~ejm43cost 1.301 · soft-core 4/10 · common core 28ejm45~ejm47cost 1.346 · soft-core 11/11 · common core 28ejm55~ejm54cost 1.488 · soft-core 5/9 · common core 28ejm55~ejm42cost 1.544 · soft-core 5/7 · common core 28ejm50~ejm43cost 1.654 · soft-core 5/10 · common core 28ejm45~ejm48cost 1.660 · soft-core 11/14 · common core 28ejm46~ejm47cost 1.759 · soft-core 8/11 · common core 28ejm47~jmc28cost 1.762 · soft-core 11/11 · common core 28ejm50~ejm44cost 1.762 · soft-core 5/13 · common core 28ejm54~ejm43cost 1.777 · soft-core 9/10 · common core 28jmc23~ejm47cost 1.785 · soft-core 8/11 · common core 28jmc27~ejm47cost 1.790 · soft-core 8/11 · common core 28ejm42~ejm46cost 1.885 · soft-core 7/8 · common core 28ejm54~ejm44cost 1.886 · soft-core 9/13 · common core 28jmc27~ejm49cost 1.892 · soft-core 8/11 · common core 28ejm49~jmc28cost 1.897 · soft-core 11/11 · common core 28ejm46~ejm49cost 1.904 · soft-core 8/11 · common core 28ejm46~ejm54cost 1.926 · soft-core 8/9 · common core 28ejm49~ejm48cost 1.938 · soft-core 11/14 · common core 28ejm31~ejm46cost 1.964 · soft-core 4/8 · common core 28ejm47~ejm48cost 1.983 · soft-core 11/14 · common core 28ejm46~ejm43cost 1.990 · soft-core 8/10 · common core 28

17 of the 17 repaired edges below can be toggled between the repaired soft-core and the one the mapper proposed. The repaired view is what is shown.

ejm46~jmc23

cost 0.273 · soft-core 1/1 · common core 35 · mapper mcss-e2

jmc23~jmc28

cost 0.276 · soft-core 1/4 · common core 35 · mapper mcss-e2

jmc27~jmc28

cost 0.294 · soft-core 1/4 · common core 35 · mapper mcss-e2

ejm46~jmc28

cost 0.322 · soft-core 1/4 · common core 35 · mapper mcss-e2

jmc23~jmc27

cost 0.328 · soft-core 1/1 · common core 35 · mapper mcss-e2

ejm31~ejm42

cost 0.347 · soft-core 1/4 · common core 31 · mapper mcss-e2

ejm46~jmc27

cost 0.387 · soft-core 1/1 · common core 35 · mapper mcss-e2

ejm31~ejm50

cost 0.431 · soft-core 1/2 · common core 31 · mapper mcss-e2

ejm31~ejm55

cost 0.447 · soft-core 4/5 · common core 28 · mapper mcss-e2

jmc27~jmc30

cost 0.474 · soft-core 1/2 · common core 35 · mapper mcss-e2

jmc30~jmc28

cost 0.545 · soft-core 2/4 · common core 35 · mapper mcss-e2

jmc23~jmc30

cost 0.558 · soft-core 1/2 · common core 35 · mapper mcss-e2

ejm42~ejm43

cost 0.588 · soft-core 1/4 · common core 34 · mapper mcss-e2

ejm46~jmc30

cost 0.620 · soft-core 1/2 · common core 35 · mapper mcss-e2

ejm50~ejm42

cost 0.674 · soft-core 2/4 · common core 31 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 2 atom(s) demoted.
(orientation flipped: sides below refer to ejm42~ejm50) closure: normalised raw soft-core 3/1 -> 4/2 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 4/2 atom(s)

ejm43~ejm44

cost 0.917 · soft-core 1/4 · common core 37 · mapper mcss-e2

ejm50~ejm55

cost 0.935 · soft-core 5/5 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 2 atom(s) demoted.
closure: normalised raw soft-core 4/4 -> 5/5 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 5/5 atom(s)

ejm31~ejm54

cost 0.945 · soft-core 4/9 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 2 atom(s) demoted.
closure: normalised raw soft-core 3/8 -> 4/9 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 4/9 atom(s)

jmc27~ejm45

cost 1.173 · soft-core 8/11 · common core 28 · mapper mcss-e2

ejm45~jmc28

cost 1.185 · soft-core 11/11 · common core 28 · mapper mcss-e2

ejm46~ejm45

cost 1.191 · soft-core 8/11 · common core 28 · mapper mcss-e2

ejm50~ejm54

cost 1.267 · soft-core 5/9 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 4 atom(s) demoted.
closure: normalised raw soft-core 3/7 -> 5/9 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 5/9 atom(s)

ejm31~ejm44

cost 1.300 · soft-core 4/13 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (3, 3) → (1, 1), 2 atom(s) demoted.
initial: 3 soft-core region(s) on side 1, 3 on side 2 iter 1 side 1: bridged 3 regions by demoting 1 atom(s) [19] [steiner:approximate] iter 1 side 2: bridged 3 regions by demoting 1 atom(s) [19] [steiner:approximate] final: 1/1 region(s), soft-core 4/13 atom(s)

ejm31~ejm43

cost 1.301 · soft-core 4/10 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (2, 2) → (1, 1), 4 atom(s) demoted.
initial: 2 soft-core region(s) on side 1, 2 on side 2 iter 1 side 1: bridged 2 regions by demoting 1 atom(s) [19] iter 1 side 2: bridged 2 regions by demoting 1 atom(s) [19] iter 1 side 1: absorbed 1 core atom(s) [29] stranded behind the soft-core iter 1 side 2: absorbed 1 core atom(s) [29] stranded behind the soft-core final: 1/1 region(s), soft-core 4/10 atom(s)

ejm45~ejm47

cost 1.346 · soft-core 11/11 · common core 28 · mapper mcss-e2

ejm55~ejm54

cost 1.488 · soft-core 5/9 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (2, 2) → (1, 1), 6 atom(s) demoted.
(orientation flipped: sides below refer to ejm54~ejm55) initial: 2 soft-core region(s) on side 1, 2 on side 2 iter 1 side 1: bridged 2 regions by demoting 1 atom(s) [30] iter 1 side 2: bridged 2 regions by demoting 1 atom(s) [29] iter 1 side 1: absorbed 2 core atom(s) [31, 32] stranded behind the soft-core iter 1 side 2: absorbed 2 core atom(s) [30, 31] stranded behind the soft-core final: 1/1 region(s), soft-core 9/5 atom(s)

ejm55~ejm42

cost 1.544 · soft-core 5/7 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 8 atom(s) demoted.
(orientation flipped: sides below refer to ejm42~ejm55) initial: 1 soft-core region(s) on side 1, 1 on side 2 iter 1 side 1: absorbed 4 core atom(s) [31, 32, 33, 34] stranded behind the soft-core iter 1 side 2: absorbed 4 core atom(s) [29, 30, 31, 32] stranded behind the soft-core final: 1/1 region(s), soft-core 7/5 atom(s)

ejm50~ejm43

cost 1.654 · soft-core 5/10 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (2, 2) → (1, 1), 6 atom(s) demoted.
(orientation flipped: sides below refer to ejm43~ejm50) closure: normalised raw soft-core 7/2 -> 8/3 atoms initial: 2 soft-core region(s) on side 1, 2 on side 2 iter 1 side 1: bridged 2 regions by demoting 1 atom(s) [19] iter 1 side 2: bridged 2 regions by demoting 1 atom(s) [19] iter 1 side 1: absorbed 1 core atom(s) [29] stranded behind the soft-core iter 1 side 2: absorbed 1 core atom(s) [29] stranded behind the soft-core final: 1/1 region(s), soft-core 10/5 atom(s)

ejm45~ejm48

cost 1.660 · soft-core 11/14 · common core 28 · mapper mcss-e2

ejm46~ejm47

cost 1.759 · soft-core 8/11 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 4 atom(s) demoted.
closure: normalised raw soft-core 6/9 -> 8/11 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 8/11 atom(s)

ejm47~jmc28

cost 1.762 · soft-core 11/11 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 4 atom(s) demoted.
closure: normalised raw soft-core 9/9 -> 11/11 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 11/11 atom(s)

ejm50~ejm44

cost 1.762 · soft-core 5/13 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (3, 3) → (1, 1), 4 atom(s) demoted.
(orientation flipped: sides below refer to ejm44~ejm50) closure: normalised raw soft-core 11/3 -> 12/4 atoms initial: 3 soft-core region(s) on side 1, 3 on side 2 iter 1 side 1: bridged 3 regions by demoting 1 atom(s) [19] [steiner:approximate] iter 1 side 2: bridged 3 regions by demoting 1 atom(s) [19] [steiner:approximate] final: 1/1 region(s), soft-core 13/5 atom(s)

ejm54~ejm43

cost 1.777 · soft-core 9/10 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (2, 2) → (1, 1), 8 atom(s) demoted.
(orientation flipped: sides below refer to ejm43~ejm54) closure: normalised raw soft-core 6/5 -> 7/6 atoms initial: 2 soft-core region(s) on side 1, 2 on side 2 iter 1 side 1: bridged 2 regions by demoting 1 atom(s) [34] iter 1 side 2: bridged 2 regions by demoting 1 atom(s) [30] iter 1 side 1: absorbed 2 core atom(s) [35, 37] stranded behind the soft-core iter 1 side 2: absorbed 2 core atom(s) [31, 32] stranded behind the soft-core final: 1/1 region(s), soft-core 10/9 atom(s)

jmc23~ejm47

cost 1.785 · soft-core 8/11 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 4 atom(s) demoted.
(orientation flipped: sides below refer to ejm47~jmc23) closure: normalised raw soft-core 9/6 -> 11/8 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 11/8 atom(s)

jmc27~ejm47

cost 1.790 · soft-core 8/11 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 4 atom(s) demoted.
(orientation flipped: sides below refer to ejm47~jmc27) closure: normalised raw soft-core 9/6 -> 11/8 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 11/8 atom(s)

ejm42~ejm46

cost 1.885 · soft-core 7/8 · common core 28 · mapper mcss-e2

ejm54~ejm44

cost 1.886 · soft-core 9/13 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (2, 2) → (1, 1), 6 atom(s) demoted.
(orientation flipped: sides below refer to ejm44~ejm54) initial: 2 soft-core region(s) on side 1, 2 on side 2 iter 1 side 1: bridged 2 regions by demoting 1 atom(s) [29] iter 1 side 2: bridged 2 regions by demoting 1 atom(s) [30] iter 1 side 1: absorbed 2 core atom(s) [30, 31] stranded behind the soft-core iter 1 side 2: absorbed 2 core atom(s) [31, 32] stranded behind the soft-core final: 1/1 region(s), soft-core 13/9 atom(s)

jmc27~ejm49

cost 1.892 · soft-core 8/11 · common core 28 · mapper mcss-e2

ejm49~jmc28

cost 1.897 · soft-core 11/11 · common core 28 · mapper mcss-e2

ejm46~ejm49

cost 1.904 · soft-core 8/11 · common core 28 · mapper mcss-e2

ejm46~ejm54

cost 1.926 · soft-core 8/9 · common core 28 · mapper mcss-e2

ejm49~ejm48

cost 1.938 · soft-core 11/14 · common core 28 · mapper mcss-e2

ejm31~ejm46

cost 1.964 · soft-core 4/8 · common core 28 · mapper mcss-e2

ejm47~ejm48

cost 1.983 · soft-core 11/14 · common core 28 · mapper mcss-e2
Soft-core repaired: regions (1, 1) → (1, 1), 4 atom(s) demoted.
closure: normalised raw soft-core 9/12 -> 11/14 atoms initial: 1 soft-core region(s) on side 1, 1 on side 2 final: 1/1 region(s), soft-core 11/14 atom(s)

ejm46~ejm43

cost 1.990 · soft-core 8/10 · common core 28 · mapper mcss-e2